MLB Probable Pitchers for Wednesday, July 22, 2026
| Pirates (52-49) | Preview | |
| Yankees (56-44) | 1:05PM |
| PIT | Mitch Keller (#23, 30, RHP, 6-7, 5.14) |
| NYY | Gerrit Cole (#45, 35, RHP, 3-5, 3.93) |
| Orioles (49-52) | Preview | |
| Red Sox (51-48) | 1:35PM |
| BAL | Dean Kremer (#64, 30, RHP, 1-2, 4.15) |
| BOS | Jake Bennett (#64, 25, LHP, 5-3, 2.35) |
| Giants (42-59) | Preview | |
| Royals (42-60) | 2:10PM |
| SFG | Landen Roupp (#65, 27, RHP, 7-8, 3.98) |
| KCR | Seth Lugo (#67, 36, RHP, 3-6, 4.39) |
| Mets (43-59) | Preview | |
| Brewers (63-38) | 2:10PM |
| NYM | Christian Scott (#45, 27, RHP, 3-1, 2.87) |
| MIL | Logan Henderson (#43, 24, RHP, 3-1, 2.97) |
| Nationals (51-51) | Preview | |
| Rockies (41-62) | 3:10PM |
| WSN | Cade Cavalli (#24, 27, RHP, 6-4, 3.78) |
| COL | Gabriel Hughes (#43, 24, RHP, 0-1, 3.14) |
| Athletics (43-58) | Preview | |
| D'backs (52-49) | 3:40PM |
| ATH | Gage Jump (#61, 23, LHP, 3-5, 3.78) |
| ARI | Merrill Kelly (#29, 37, RHP, 7-8, 5.20) |
| Reds (46-54) | Preview | |
| Mariners (51-51) | 3:40PM |
| CIN | Brady Singer (#51, 29, RHP, 4-9, 4.56) |
| SEA | Emerson Hancock (#26, 27, RHP, 6-4, 3.17) |
| Cardinals (51-49) | Preview | |
| Angels (41-61) | 4:07PM |
| STL | Hunter Dobbins (#40, 26, RHP, 1-1, 4.03) |
| LAA | Reid Detmers (#48, 26, LHP, 3-6, 4.16) |
| Dodgers (64-38) | Preview | |
| Phillies (56-46) | 6:40PM |
| LAD | Eric Lauer (#33, 31, LHP, 4-5, 4.81) |
| PHI | Aaron Nola (#27, 33, RHP, 3-7, 5.68) |
| Twins (49-53) | Preview | |
| Guardians (54-48) | 6:40PM |
| MIN | Bailey Ober (#17, 30, RHP, 7-3, 4.32) |
| CLE | Slade Cecconi (#44, 27, RHP, 4-6, 4.55) |
| Pirates (52-49) | Preview | |
| Yankees (56-44) | 7:05PM |
| PIT | Bubba Chandler (#36, 23, RHP, 3-8, 4.77) |
| NYY | Max Fried (#54, 32, LHP, 4-3, 3.21) |
| Rays (58-42) | Preview | |
| Blue Jays (46-55) | 7:07PM |
| TBR | Griffin Jax (#22, 31, RHP, 5-7, 4.08) |
| TOR | Braydon Fisher (#63, 25, RHP, 3-3, 3.65) |
| Orioles (49-52) | Preview | |
| Red Sox (51-48) | 7:10PM |
| BAL | Kyle Bradish (#38, 29, RHP, 6-9, 3.61) |
| BOS | Eduardo Rivera (#99, 23, LHP, 0-0, 2.89) |
| Padres (50-51) | Preview | |
| Braves (58-42) | 7:15PM |
| SDP | Michael King (#34, 31, RHP, 6-7, 3.34) |
| ATL | Martín Pérez (#33, 35, LHP, 6-6, 3.54) |
| White Sox (53-47) | Preview | |
| Rangers (51-50) | 8:05PM |
| CHW | Anthony Kay (#18, 31, LHP, 6-4, 4.24) |
| TEX | Tyler Alexander (#13, 31, LHP, 1-1, 2.79) |
| Marlins (52-50) | Preview | |
| Astros (49-54) | 8:10PM |
| MIA | Sandy Alcantara (#22, 30, RHP, 10-5, 3.89) |
| HOU | Peter Lambert (#38, 29, RHP, 8-5, 3.03) |
| Tigers (47-54) | Preview | |
| Cubs (57-44) | 8:10PM |
| DET | Keider Montero (#54, 25, RHP, 6-5, 3.22) |
| CHC | Colin Rea (#53, 35, RHP, 7-6, 4.74) |


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