| OSC | Ontario Securities Commission | |
| OSC | Organisations de la Société Civile (French) | |
| OSC | Office of Special Counsel | |
|
| OSC | Oscillograph (electrical engineering) | |
| OSC | Oscillator | |
| OSC | Ontario Science Centre (Canada) | |
| OSC | Order to Show Cause | |
| OSC | Office of Science (US Department of Energy) | |
| OSC | Osceola (Amtrak station code; Osceola, IA) | |
| OSC | Organizaciones de la Sociedad Civil (Spanish: Civil Society Organizations) | |
| OSC | OpenSound Control | |
| OSC | Orlando Science Center | |
| OSC | Oklahoma State Cowboys (Oklahoma State University; Stillwater, OK) | |
|
| OSC | Office of the State Controller | |
| OSC | Open Source Community (computing) | |
| OSC | Ohio Supercomputer Center | |
| OSC | Orson Scott Card (science fiction author) | |
| OSC | Office of the Secretary of the Commonwealth (various locations) | |
| OSC | Open Space Conservation (zoning; various locations) | |
| OSC | Office of Student Conduct (various schools) | |
| OSC | Official Supporters Club (fan clubs) | |
| OSC | Object Show Community | |
| OSC | On-Scene Coordinator | |
| OSC | Oregon State College | |
| OSC | One Step Closer | |
| OSC | Outpatient Surgery Center (various locations) | |
| OSC | Optical Supervisory Channel | |
| OSC | Optical SuperComputing (workshop) | |
| OSC | Optical Service Channel (Ciena) | |
| OSC | Osaka Station City (Osaka, Japan) | |
| OSC | Orbital Sciences Corporation | |
| OSC | Olympic Studies Centre (International Olympic Committee) | |
| OSC | Other Significant Contributor (status; various organizations) | |
| OSC | Operation Support Center (Schaumburg, IL) | |
| Osc | Oscan (linguistics) | |
| OSC | On-Scene Commander | |
| OSC | Operations Service Center (various companies) | |
| OSC | Occupational Safety Committee (various locations) | |
| OSC | Organisationsberatung Supervision Coaching (German: Organizational Consulting Coaching Supervision; publication) | |
| oSC | openSUSE Conference (computing) | |
| OSC | Office of Scholarly Communication | |
| OSC | On Site Consultant | |
| OSC | Operation Second Chance (Clarksburg, MD) | |
| OSC | Overview and Scrutiny Committee | |
| OSC | Ohio Supreme Court (judiciary) | |
| OSC | Omics Science Center (Japan) | |
| OSC | Oakville Soccer Club (est. 1972; Oakville, Ontario, Canada) | |
| OSC | Operation Safe Commerce | |
| OSC | Operations Support Center | |
| OSC | Officer's Spouses' Club (USAF) | |
| OSC | Operations Section Chief | |
| OSC | Operating System Capabilities (computing) | |
| OSC | Oxygen Storage Capacity | |
| OSC | Out-of-School Care | |
| OSC | Operations Support Command | |
| OSC | Olney Swim Center (Olney, MD) | |
| OSC | Official Staff Commentary (various organizations) | |
| OSC | Online Support Center (various organizations) | |
| OSC | Operational Support Command (US DoD) | |
| OSC | On Screen Controller (media players) | |
| OSC | Office of Special Concerns (Philippines) | |
| OSC | Optical Signature Code | |
| OSC | Open Space Council (various locations) | |
| OSC | Open Source Culture (software) | |
| OSC | Objective Supply Capability | |
| OSC | Optical Scanning Cryptography | |
| OSC | Open Star Clusters (astronomy) | |
| OSC | Own-Ship Course | |
| OSC | Optical Sensor Converter | |
| OSC | Operations Systems Center | |
| OSC | Old State Capitol (Louisiana) | |
| OSC | Office Symbol Code | |
| OSC | Organization Structure Code | |
| OSC | Office of Security Cooperation | |
| OSC | Oxford Supercomputing Centre | |
| OSC | Oxford Soccer Club (Oxford, NC) | |
| OSC | Osteoporosis Society of Canada | |
| OSC | Online Service Centre | |
| OSC | Online Support Community (various organizations) | |
| OSC | Ocean Sailing Club | |
| OSC | Official Supporting Committee | |
| OSC | Operations Summary Console | |
| OSC | Other Significant Causes (autopsy report) | |
| OSC | Oncological Sciences Center (Purdue University; Indiana) | |
| OSC | Open Source Curriculum (computing resource) | |
| OSC | Operating System Chooser | |
| OSC | Operation Summary Console | |
| OSC | Oregon Spirit Chorus (Salem, OR) | |
| OSC | Ogden Service Center | |
| OSC | On-Site Certification (various organizations) | |
| OSC | Optical Selective Combiner | |
| OSC | Object Sub-class Code | |
| OSC | Open Set Condition (mathematics) | |
| OSC | Office of Space Communications (NASA) | |
| OSC | Oil Spill Commission | |
| OSC | Open Source Creativity | |
| OSC | Canons Regular of the Order of the Holy Cross, Crosier Fathers (religious order) | |
| OSC | Overlapped-Subarray Correlogram | |
| OSC | Oregon Stroke Center (est. 1979) | |
| OSC | Outside Speakers Committee | |
| OSC | Organizational Supply Code | |
| OSC | Overseas Senior Cambridge | |
| OSC | Obstruent Sequencing Constraint | |
| OSC | Chief Operations Specialist (US Navy) | |
| OSC | Onshore Slug Catcher | |
| OSC | Ontario Systems Corporation | |
| OSC | Operating System Component | |
| OSC | Ocean Shipping Consultants Limited (Surrey, England) | |
| OSC | Own Ship's Course | |
| OSC | Operational Status Check (readiness test step, especially used for voting systems hardware) | |
| OSC | Olympic Sports Club | |
| OSC | Online Sexual Compulsivity | |
| OSC | Office of Standards Compliance | |
| OSC | Operations Support Call | |
| OSC | Opportunistic Secondary Channel | |
| OSC | Open Space Cooling System | |
| OSC | Operational Site Certification | |
| OSC | Office Supply Connection (Minnesota) | |
| OSC | Operators Services Complex | |
| OSC | Oneway Subjourney Check for Normal Fares (airfare construction) | |