First legs: 19 February

Fenerbahçe vs Nottingham Forest (18:45 CET) GNK Dinamo vs Genk (18:45 CET) PAOK vs Celta (18:45 CET) Brann vs Bologna (18:45 CET) Celtic vs Stuttgart Lille vs Crvena Zvezda Panathinaikos vs Viktoria Plzeň Ludogorets vs Ferencváros

Second legs: 26 February

Viktoria Plzeň vs Panathinaikos (18:45 CET) Ferencváros vs Ludogorets (18:45 CET) Crvena Zvezda vs Lille (18:45 CET) Stuttgart vs Celtic (18:45 CET) Bologna vs Brann Genk vs GNK Dinamo Nottingham Forest vs Fenerbahçe Celta vs PAOK