A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Åsberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression.
The study has not yet been published. But MindBio’s CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was “in front of the curve in microdosing research.”
Tomorrows headline “Microdosing better than a cup of coffee for depression.”
RFK later that day: “We’re outlawing depression. The CEO of Starbucks will be our new Smile Enforcement Czar. Coffee is now mandatory.”
He really is a zero master. Whatever decision he makes regarding any subject is surely the wrong answer.
Title is horrible. One study shows these benefits. Do not make empiric claims like that.
Usually places don’t like editorialized titles, but here I really would just like to add [sensational title] or something at the end.
Do it
Most people talking about microdosing are referring to shrooms (psilocybin), not LSD though
Microdosing really just refers to taking sub-perceptual amounts of a given substance. It equally applies to things like THC and LSD as it does to shrooms.
Really? I associate it with LSD. Isn’t it more difficult with mushrooms as psilocybin concentration fluctuates? I guess you could extract it. Never really thought about it.
Grind it up and put it in pills. The resulting pills will have approximately the same doses
The fluctuation doesn’t make enough difference to switch between a microdose to a macrodose. But don’t depend on the shake scraps at the bottom of the bag, because that stuff actually can vary wildly
Ime the shroom powder is what can kick your ass the most
I have accidentally BOOMED on the space dust at the bottom of the bag
Yeah microdosing LSD seems crazy to me because it lasts so much longer than shrooms. When I’ve heard of microdosing it’s usually been referring to shrooms
I’d have to think that this report is looked unfavorably upon by the machine elves.
Maybe they should try macrodosing
Fuckoff, I’ll keep doing my own microdosing research.
For science OFC.
I like a nice placebo now and again, though.
Alcoholic kind of mood
Lose my clothes, lose my lube
Cruising for a piece of fun
Looking out for number one
Different partner every night
So narcotic outta sight
What a gas, what a beautiful assAnd it all breaks down at the role reversal
Got the muse in my head she’s universal
Spinnin’ me round she’s coming over me
And it all breaks down at the first rehearsal
Got the muse in my head she’s universal
Spinnin’ me round she’s coming over me
I somewhat assume you need a macro dose first. Your body needs to understand what the chemicals do.
Then when you microdose your body recognizes the chemicals and refreshed your subconscious memories about the state of mind.
Id love to see some science about microdosing in general, not just with psychedelics.
In my anecdotal experience, when I’ve done shrooms the depression benefits feel like they came not so much from the chemical itself but from the mindset it puts you in. That perspective, combined with the plastic state shrooms put you in has felt the most useful.
It allows you to reevaluate your life and gain perspective on it, while that plasticity actually lets those things stick.
When you microdose sure you might see some of those benefits, but you don’t really enter that altered state of mind where, imo, the real benefits come from.
This is why I think therapy guided sessions are likely the future of psychedelic treatment for mental illnesses like depression.
Isn’t a cup of coffee just microdosing with caffeine?
Yeah, coffee is definitely not a placebo
and if its like how me and my friends make our coffee…more sugar than coffee. A mug of sugar keeps the depression away?
Why not both?
I used to our a bit of shrooms in my coffee. It’s actually tasting ok.
