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Researchers at Stanford Medicine report that blocking a protein linked to aging can restore cartilage that naturally wears away in the knees of older mice. In the study, the injectable treatment not only rebuilt cartilage but also stopped arthritis from developing after knee injuries similar to ACL tears, which are common among athletes and active adults. A pill-based version of the same therapy is already being tested in clinical trials aimed at treating muscle weakness associated with aging.

In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

A treatment that blocks an age-related protein restored cartilage in aging and injured joints by reprogramming existing cells rather than using stem cells.

In mice (of course) and human tissue exvivo. Earlier phase 1 studies with 15-PGDH has shown that it is safe and active in healthy volunteers.

*A treatment that blocks an age-related protein restored cartilage in aging and injured joints by reprogramming existing cells rather than using stem cells.*

…The universality of the UV-to-X-ray relation underpins certain methods that use quasars as “standard candles” to measure the geometry of the universe and ultimately probe the nature of dark matter and dark energy. This new result highlights the necessity for caution, demonstrating that the assumption of unchanging black hole structure across cosmic time must be rigorously re-examined…

What I don’t get is why it took them decades to figure this out. Why have they been giving us sugar substitutes without understanding what they have been doing to us? Why were these approved for use in the first place?

What I don’t get is why it took them decades to figure this out. Why have they been giving us sugar substitutes without understanding what they have been doing to us? Why were these approved for use in the first place?

Researchers at Tohoku University have developed a method to detect dark matter by connecting quantum sensors in optimized networks, potentially solving one of physics’ greatest mysteries[^1]. The quantum network approach aims to boost sensor sensitivity to detect the faint traces dark matter may leave behind, though it cannot be directly observed[^2].

Researchers at Tohoku University have developed a method to detect dark matter by connecting quantum sensors in optimized networks, potentially solving one of physics’ greatest mysteries[^1]. The quantum network approach aims to boost sensor sensitivity to detect the faint traces dark matter may leave behind, though it cannot be directly observed[^2].

Scientists have uncovered that mushrooms evolved the ability to make psilocybin not once but twice, using completely different biochemical toolkits.

A new tool developed at ETH Zurich, MetaGraph, allows scientists to search through vast public DNA and RNA databases in seconds — like a “Google for DNA.”

In a newly funded federal study published in the Journal of the National Cancer Institute, researchers at Mass General Brigham demonstrated that their liquid biopsy test, called HPV-DeepSeek, can detect HPV-related head and neck cancers as early as 10 years before symptoms develop. According to the study’s authors, diagnosing these cancers earlier could increase treatment success rates and reduce the need for aggressive therapies.

Scientists at UNSW have achieved a breakthrough in quantum computing by entangling nuclear spins across distances of up to 20 nanometers in a silicon chip - the same scale as modern computer transistors[^1].

Scientists at UNSW have achieved a breakthrough in quantum computing by entangling nuclear spins across distances of up to 20 nanometers in a silicon chip - the same scale as modern computer transistors[^1].

Panama’s seasonal upwelling collapsed in 2025, linked to reduced winds. The event signals risks for fisheries and climate-sensitive ocean processes.

Scientists have recreated a crucial step that may have set life in motion nearly four billion years ago.

This does not imply that the emergence of life was impossible, but it suggests that current knowledge may be lacking. The research highlights that identifying the physical principles behind life’s rise from nonliving matter remains one of the greatest challenges in biological physics.

Water-rich sub-Neptunes may offer key clues to where life could exist beyond Earth. For astrobiologists, the hunt for life outside our solar system begins with the same question you would ask in a desert: where is the water? Among the planets discovered so far, a very common type appears to have interiors rich in water. These worlds are known as “sub-Neptunes” because their size and mass fall between Earth and Neptune.

When we look at the night sky, it can appear as though our cosmic surroundings are filled with countless stars, planets, and galaxies. However, researchers have long proposed that our local region of the universe may contain far fewer galaxies than expected.

Around 4.6 billion years ago, the solar system took shape out of a vast swirl of gas and dust surrounding the Sun. The asteroids that remain today are among the most complete relics from that chaotic era, comparable to scraps and spare parts left behind at a construction site. By analyzing their shapes, surfaces, and chemical makeup, scientists can uncover clues about what conditions were like when the solar system first formed.

Life Before the Great Dying

A Geometry for the Universe

In a groundbreaking discovery, scientists have found chemical traces of betel nut chewing in 4,000-year-old teeth from a Bronze Age burial in Thailand — the earliest direct evidence of psychoactive plant use in Southeast Asia.

For the first time, TTV enabled the detection of a super-Earth named Kepler-725c, which is about 10 times the mass of Earth and orbits within the habitable zone of a Sun-like star, Kepler-725. The findings were published in Nature Astronomy.

A rare fossil in Dominican amber unveils a miniature, ancient “dirt ant” once native to the Caribbean. Ants are a common sight wherever soil is found, but one group is so expertly camouflaged that they have earned the exclusive name “dirt ants” (Basiceros).

Researchers found that earthquake-driven rock fractures can power deep-Earth life by splitting water into energy-rich compounds.

Researchers engineered a graphene-encased catalyst with ultra-low platinum use that delivers high-efficiency, industrial-scale hydrogen production.

In a dramatic new discovery, scientists have identified over 15,000 kilometers of ancient riverbeds on Mars, revealing that vast regions of the planet were once crisscrossed by flowing water.

about time. Thanks Bristol

...when atacamite is exposed to a magnetic field, its temperature changes, a rare and valuable behavior that could help shape the future of cooling technologies...

A bold new era in space science has begun: ESA and OHB have officially partnered to launch LISA, the world’s first space-based gravitational wave observatory.

In its latest observation, Webb captured an image of 14 Herculis c, a frigid giant planet orbiting a star 60 light-years from Earth. From this single, cold speck in space, researchers are uncovering new details about the planet’s temperature, unusual orbit, and even how its atmosphere behaves, offering a rare glimpse into the strange dynamics of alien worlds.

To better understand the metabolism of what were likely among the first living organisms on Earth, a research team led by Professor William Orsi from LMU’s Department of Earth and Environmental Sciences conducted laboratory simulations mimicking early Earth conditions, dating back 4 to 3.6 billion years. These simulations replicated aspects of modern hydrothermal vents known as “black smokers” on the ocean floor. However, a key difference was that the ancient oceans contained much higher levels of dissolved iron.

Natural hydrogen trapped in the Earth’s crust could power humanity for millennia, and without emissions. A new strategy maps out how to find it.

Scientists have uncovered a seismic signature beneath Mars’ surface that hints at something astonishing—liquid water may still exist in the planet’s upper crust.

Researchers uncover why the body may keep reacting to a hidden threat even long after the bacteria are gone.

Super-Earths, larger planets similar to Earth, are far more common across the universe than scientists previously believed, according to a groundbreaking microlensing study using KMTNet telescopes.

Previous studies have consistently shown a long-term trend of mass loss, particularly in West Antarctica and the Antarctic Peninsula, while glaciers in East Antarctica appeared relatively stable. However, a recent study led by Dr. Wang and Prof. Shen at Tongji University has found a surprising shift: between 2021 and 2023, the AIS experienced a record-breaking increase in overall mass.

It's Virginia, Colorado, and Texas.

A newly identified fossil species dating back 444 million years has been officially named Keurbos susanae, in honor of the scientist’s mother, affectionately known as Sue.

WEHI scientists discovered a drug that blocks long COVID in mice and may improve acute treatment options beyond current antivirals like Paxlovid.

“I don’t think it was a ‘Eureka!’ moment whereby hominins first made a sharp stone flake by intention or by accident and then went to look for something to cut,” says Eren. “There is no reason to produce sharp stone tools unless the need to cut is already in place.”

archived (Wayback Machine)

archived (Wayback Machine)

Perseverance just stumbled upon one of Mars’ weirdest rocks yet—a formation covered in dark, spherical shapes with mysterious textures that have scientists buzzing.

Penrose for the win!

What if water and hydrogen don’t stay separated inside planets like Earth and Neptune? New research from UCLA and Princeton shows that under extreme heat and pressure, these elements mix and even “rain out” within young planets.

An outbreak of tuberculosis (TB), a lung disease often marked by a persistent cough, began in January 2024 in Kansas City, Kansas, and two neighboring counties. As of early March 2025, the outbreak is ongoing. So far, 147 people have been diagnosed, with 67 developing symptoms. The remaining 80 cases are classified as latent infections, meaning the individuals carry the bacteria but do not show symptoms.

Ultrafast electron imaging reveals never-before-seen nuclear motions in hydrocarbon molecules triggered by light. The interaction between hydrocarbon molecules and light can influence the formation of nitrous acid in the atmosphere, a compound that plays a significant role in air pollution. In this study, researchers investigated how proton transfer contributes to these light-induced molecular processes.

A new Swedish study reveals that many common office coffee machines fail to filter out cholesterol-elevating compounds found in coffee, sometimes leaving behind even more than espresso or French press. Depending on the machine and brewing method, the amount of harmful diterpenes like cafestol and kahweol can vary widely, and frequent coffee drinkers may be unknowingly boosting their LDL cholesterol levels.

A new Swedish study reveals that many common office coffee machines fail to filter out cholesterol-elevating compounds found in coffee, sometimes leaving behind even more than espresso or French press. Depending on the machine and brewing method, the amount of harmful diterpenes like cafestol and kahweol can vary widely, and frequent coffee drinkers may be unknowingly boosting their LDL cholesterol levels.

If there’s anything we’ve learned from the coronavirus pandemic, it’s that washing our hands is one of the best ways to protect ourselves from the dangers of contagion. But hand washing does much more than cleanse us physically; sometimes it can wipe our mental slate clean. Here are some examples of what a bit of soap can do for our psyches.

Perovskite LEDs are emerging as a game-changing technology, offering vibrant colors, lower costs, and easier manufacturing compared to traditional LEDs.

Researchers at the University of Reading tested participants who ate a walnut-enriched breakfast and found significant cognitive benefits compared to a nut-free meal. The study highlights the potential of walnuts as a natural brain enhancer, but more research is needed to fully understand their impact.

Poor sleep quality alters immune function, increasing inflammation and disease risk. One night of sleep loss can mimic immune changes seen in obesity, stressing the importance of sleep for overall health.

A breakthrough in renewable energy research has led to the development of a cost-effective and highly efficient iron-based catalyst for water oxidation.