MeSH

A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.

Year introduced: 1991

A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.

Year introduced: 2003

A class of proteins related in structure and function to TATA-BOX BINDING PROTEIN that can take the place of TATA-BOX BINDING PROTEIN in the transcription initiation complex. They are found in most multicellular organisms and may be involved in tissue-specific promoter regulation. They bind to DNA and interact with TATA-BINDING PROTEIN ASSOCIATED FACTORS, however they may lack specificity for the TATA-BOX.

Year introduced: 2003

required in emryonic development; RefSeq NM_214796

involved in cell-cycle regulation; hTAFII250 & CCG1 genes are identical; do not confuse with template activating factor-1; RefSeq NM_138923 (human); XM_194622 (mouse)

GenBank BK005774

GenBank AL663067

a TBP-associated factor of SL1 that functions in RNA polymerase I transcription; TBP - TATA-binding protein; TAF - TBP-associated factor; RefSeq NM_024116

RefSeq NM_015975

RefSeq NM_004865

RefSeq NM_139215

RefSeq NM_003185

RefSeq NM_133966

RefSeq NM_146092

GenBank AY463628

RefSeq NM_003194

component of transcription factor TFIID; coactivator of p53; RefSeq NM_133615

RefSeq NM_001100449

RefSeq NM_139353

TAF - TATA-binding protein Associated Factor; an integral component of SL1, a RNA polymerase I transcription factor; RefSeq NM_021441