MeSH

A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

Year introduced: 1966(1965)
Date introduced: January 1, 1999

Date introduced: December 28, 1981

a lipophilic prodrug of BrdU; structure given in first source

Date introduced: July 27, 1993

Date introduced: January 1, 1977

5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.

Year introduced: 1974(1971)
Date introduced: January 1, 1999