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Increased homozygosity due to endogamy results in fitness consequences in a human population.
Swinford NA, Prall SP, Gopalan S, Williams CM, Sheehama J, Scelza BA, Henn BM. Swinford NA, et al. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2309552120. doi: 10.1073/pnas.2309552120. Epub 2023 Oct 17. Proc Natl Acad Sci U S A. 2023. PMID: 37847737 Free PMC article.
Using a sample of 681 individuals, we show that Himba exhibit elevated levels of "inbreeding," calculated as the fraction of the genome in runs of homozygosity (F(ROH)). Many individuals contain multiple long segments of ROH in their genomes, indicating that their parents …
Using a sample of 681 individuals, we show that Himba exhibit elevated levels of "inbreeding," calculated as the fraction of the genome in r …
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans.
Henn BM, Gignoux CR, Jobin M, Granka JM, Macpherson JM, Kidd JM, Rodríguez-Botigué L, Ramachandran S, Hon L, Brisbin A, Lin AA, Underhill PA, Comas D, Kidd KK, Norman PJ, Parham P, Bustamante CD, Mountain JL, Feldman MW. Henn BM, et al. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5154-62. doi: 10.1073/pnas.1017511108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383195 Free PMC article.
We analyzed geographic patterns of linkage disequilibrium and population differentiation, as measured by F(ST), in Africa. The observed patterns are consistent with an origin of modern humans in southern Africa rather than eastern Africa, as is generally assumed. ...
We analyzed geographic patterns of linkage disequilibrium and population differentiation, as measured by F(ST), in Africa. The observ …
An alternative to the goodness of fit.
Henn J. Henn J. Acta Crystallogr A Found Adv. 2016 Nov 1;72(Pt 6):696-703. doi: 10.1107/S2053273316013206. Epub 2016 Oct 6. Acta Crystallogr A Found Adv. 2016. PMID: 27809209
These correlations corrupt the GoF and lead to artificially reduced values in the GoF and in the numerical value of the wR(F(2)). Remaining systematic errors in the data sets are veiled by this mechanism. In data sets where these correlations do not appear for the entire d …
These correlations corrupt the GoF and lead to artificially reduced values in the GoF and in the numerical value of the wR(F(2)). Rem …
More about residual values.
Henn J, Schönleber A. Henn J, et al. Acta Crystallogr A. 2013 Nov;69(Pt 6):549-58. doi: 10.1107/S0108767313022514. Epub 2013 Oct 2. Acta Crystallogr A. 2013. PMID: 24132216
The prediction of R values as presented here is applicable to any field where model parameters are fitted to data with known precision. For crystallographic applications, F(2)-based residual benchmark values are given. They depend on the first and second moments of varianc …
The prediction of R values as presented here is applicable to any field where model parameters are fitted to data with known precision. For …