The rationale for pursuing the development and use of Germ-Line selection and modification techniques is examined in this essay. The argument is put forth that it is the moral obligation of the medical profession to make available to the public any technology that can cure or prevent pathology leading to death and disability, in both the present and future generations. Society should pursue the development of strategies for preventing or correcting, at the Germ-Line level, genetic features that will lead to, (...) or enhance, pathological conditions. Because prenatal screening and even early embryo screening and selection can prevent only a subset of known genetic disorders, direct genetic intervention is the only way in which certain couples can exercise their rights to reproductive health. Finally, the arguments most often raised against the pursuit of and use of methods for Germ-Line intervention shall be discussed. Keywords: Germ-Line therapy, pre-implantation embryo screening gamete modification, risk and uncertainty CiteULike Connotea Del.icio.us What's this? (shrink)

Germ cells are cross-roads of development and evolution. They define the origin of every new generation and, at the same time, represent the biological end-product of any mature organism. Germ cells are endowed with the following capacities: to store a self-descriptive program, to accumulate a protein-synthesizing machinery, and to incorporate enough nourishment to sustain embryonic development. To accomplish this goal, germ cells do not simply unfold a pre-determined program or realize a sole instructive role. On the contrary, due to the (...) complexity of their cytoarchitecture and the nature of the soma-to-germ interactions, they are heavily involved in processes of sign recognition and meaningful tissue exploration. At each stage of their inward migration, germ plasma membranes act as semiotic interfaces allowing cells to interact with the surrounding extracellular milieu and experience the compatibility of selected developmental sequences. The question of which signaling pathways are activated at each developmental stage does not result from a strictly predetermined program instructing germ cell stemness. Rather, each developmental sequence is an open-ended semiotic relationship explored and gradually defined during evolution by the context-dependency of specific cell-to-cell interactions. In this way, any structural and functional novelty that has emerged in the course of germ cell interactions may be interpreted as an exaptation fixed in the species genome in response to specific environmental constraints. (shrink)

In his left-libertarian theory of justice Hillel Steiner introduces the idea of conceiving our germ-line genetic information as a natural resource as a means to achieving luck-egalitarian equality. This idea is very interesting in and of itself. But it also has the potential of turning Steiner’s theory into a particularly powerful version of left-libertarianism, or so I argue in the first part of this paper. In the second part I critically examine this idea. I show why, in contrast to what (...) Steiner claims, this idea requires us to evaluate not only the pieces of GLGI that we have used, but rather all the pieces of GLGI that our bodies deliver throughout our lives. Then I argue that besides the immense technical difficulties involved in meeting this requirement, which we may overcome in the future, there is also a substantive reason why we cannot meet this requirement. The relevant value of any given piece of GLGI depends on the way it would interact with another piece of GLGI of the opposite sex in a reproductive process. But there is no way of determining which pieces of GLGI should be assigned to each other for the purpose of this evaluation. (shrink)

A collection of the author's new and reprinted papers in general jurisprudence. Chapters: -/- Introduction: A Philosophy of Legal Philosophy -/- Law, As Such 1. The Concept of Law Revisited 2. Law as a Means 3. Custom and Convention at the Foundations of Law 4. Realism and the Sources of Law 5. Feminism in Jurisprudence -/- Law and Morality 6. The Germ of Justice 7. The Inseparability of Law and Morals 8. The Morality in Law 9. The Role of a (...) Judge 10. Should Law Improve Morality? -/- The Demands of Law 11. Hume on Allegiance 12. Associative Obligations and the State 13. The Forces of Law 14. The Duty to Govern. (shrink)

Race proved not merely a disadvantage in securing access to prompt and appropriate medical care, but often became a life and death issue for blacks in the American South during the early decades of the twentieth century. This article investigates the impact some of the new academic disciplines such as anthropology, evolutionary biology, racially based pathology and genetics had in promoting scientific racism. The disproportionately high morbidity and mortality rates among blacks were seen as a consequence of inherent racial deficiencies (...) that rendered any attempt to ameliorate their situation as futile. While the belief in a different pathology in blacks initially deterred most health officials from taking any action, advances in medicine and microbiology, in particular the germ theory, stirred a variety of responses out of sheer self preservation, as fears among whites at the first sign of an epidemic initiated sporadic and limited actions. Ironically, in an era of deepening scientific racism, public health initiatives based on a better understanding of disease causing microorganisms, gradually improved black health. However, some public health measures were hijacked by eugenicists and racists and, rather than addressing the ill health of blacks, public health policy complied with the new laws of heredity by promoting drastic measures such as involuntary sterilization or even abortion. This further complicated the strained relationship between southern blacks and health care professionals and effected ongoing distrust towards public healthcare services. (shrink)

: Genetic interventions raise a host of moral issues and, of its various species, germ-line genetic enhancement is the most morally contentious. This paper surveys various arguments against germ-line enhancement and attempts to demonstrate their inadequacies. A positive argument is advanced in favor of certain forms of germ-line enhancements, which holds that they are morally permissible if and only if they augment Rawlsian primary goods, either directly or by facilitating their acquisition.

In most discussions of the social justice implications of new genetic technologies, enhancements are considered to be highly contentious. This is particularly so when we speak of enhancements that benefit the recipient in positional terms and enhancements that are germ-line and which can be passed on to future generations. I argue that the egalitarian reluctance, as displayed by Max Mehlman (2003:2005), to permitting enhancements is overblown. Recent writings from Buchanan (2008) and Farrelly (2004) highlight a more positive, context-dependent, role for (...) permitting the socio-economically advantaged the freedom to gain access to enhancements, including enhancements of traits associated with positional or competitive advantage. I argue that this reasoning also (necessarily) applies to germ-line enhancements or, at least, to 'effective germ-line enhancements.' In other words, I argue that such enhancements should be more seriously considered in terms of this positive context-dependent role. Nevertheless, this support is not unqualified. I critically re-examine concerns regarding the notion of the genetic underclass and I raise some worries about the possible adverse consequence of such a regulatory framework on sustaining the required egalitarian ethos. Importantly, such worries (and suggestions to address them) will be focused on the adverse effects of inequalities, rather than germ-line enhancements themselves. (shrink)

An analysis of Derrida’s early work engaging Plato, Hegel, and the life sciences. Germs of Death explores the idea of genesis, or dissemination, in the early work of Jacques Derrida. Looking at Derrida’s published and unpublished work from “Force and Signification” in 1963 to Glas in 1974, Mauro Senatore traces the development of Derrida’s understanding of genesis both linguistically and biologically, and argues that this topic is an overlooked thread that draws together Derrida’s readings of Plato and Hegel. Demonstrating (...) how Derrida’s analysis liberates the understanding of genesis from Platonic and Hegelian presupposition, Senatore also highlights Derrida’s engagement with the biological thought of his day. Senatore also shows that the implications of Derrida’s insights extend into contemporary ethical and political questions relating to postgenomic conceptions of life. “Senatore here demonstrates with stunning insight, clarity, and economy that Derrida’s work of the 1960s and ’70s needs to be understood as a radical critique or deconstruction of both the philosophical concept of life (from Plato to Hegel) and the prevailing biological model of heredity as a ‘genetic program.’ It will be impossible henceforth to read Derrida on questions of the trace, dissemination, life, and so on, without coming to terms with ‘the germs of death.’” — Michael Naas, author of The End of the World and Other Teachable Moments: Jacques Derrida’s Final Seminar “The book represents a major contribution to the field of Derrida studies and phenomenology, particularly its attention to the concept of genesis that formed the basis of Derrida’s earliest study of Husserl and the origin of his concept of writing. The unique contribution is the inclusion of the works from the periods of the mid-1970s, which have been neglected in the mainstream scholarship on Derrida.” — Gregg Lambert, author of Philosophy after Friendship: Deleuze’s Conceptual Personae. (shrink)

Understanding the dynamics of information is crucial to many areas of research, both inside and outside of philosophy. Using computer simulations of three kinds of information, germs, genes, and memes, we show that the mechanism of information transfer often swamps network structure in terms of its effects on both the dynamics and the fitness of the information. This insight has both obvious and subtle implications for a number of questions in philosophy, including questions about the nature of information, whether (...) there is genetic information, and how to arrange scientific communities. (shrink)

Somatic cell gene therapy has yielded promising results. If germ cell gene therapy can be developed, the promise is even greater: hundreds of genetic diseases might be virtually eliminated. But some claim the procedure is morally unacceptable. We thoroughly and sympathetically examine several possible reasons for this claim but find them inadequate. There is no moral reason, then, not to develop and employ germ-line gene therapy. Taking the offensive, we argue next that medicine has a prima facie moral obligation to (...) do so. (shrink)

August Weismann is famous for having argued against the inheritance of acquired characters. However, an analysis of his work indicates that Weismann always held that changes in external conditions, acting during development, were the necessary causes of variation in the hereditary material. For much of his career he held that acquired germ-plasm variation was inherited. An irony, which is in tension with much of the standard twentieth-century history of biology, thus exists – Weismann was not a Weismannian. I distinguish three (...) claims regarding the germ-plasm: (1) its continuity, (2) its morphological sequestration, and (3) its variational sequestration. With respect to changes in Weismann’s views on the cause of variation, I divide his career into four stages. For each stage I analyze his beliefs on the relative importance of changes in external conditions and sexual reproduction as causes of variation in the hereditary material. Weismann believed, and Weismannism denies, that variation, heredity, and development were deeply intertwined processes. This article is part of a larger project comparing commitments regarding variation during the latter half of the nineteenth century. (shrink)

: The current difference in attitude toward germ-line enhancement in humans and nonhumans is unjustified. Society should be more cautious in modifying the genes of nonhumans and more bold in thinking about modifying our own genome. I identify four classes of arguments pertaining to germ-line enhancement: safety arguments, justice arguments, trust arguments, and naturalness arguments. The first three types are compelling, but do not distinguish between human and nonhuman cases. The final class of argument would justify a distinction between human (...) and nonhuman germ-line enhancement; however, this type of argument fails and, therefore, the discrepancy in attitude toward human and nonhuman germ-line enhancement is unjustified. (shrink)

Richard Wollheim grew up lonely and sad in London's wealthy suburbs during the 1920s and 1930s, yet his was a childhood more interesting than most. He had an impresario father and a “Gaiety Girl” mother; together they attracted important guests (Diaghilev, Kurt Weill, Serge Lifar) to the grand houses and hotels that punctuated the landscape of Wollheim's early years. Germs is his account of that time, of the years he spent adoring his charming but distant father; of his regret (...) for loathing his beautiful, mindless mother. Told in prose that with hypnotic ease moves from deadpan comedy to poignant loneliness, Germs is already a classic work of memoir. (shrink)

Germ-line gene therapy, like many other medical technologies, raises questions of special concern to Christians. It not only raises questions about medical effects, actual or possible, of genetic interventions that would be inherited from one generation to another but also, more importantly, raises anthropological questions and so questions about parental attitudes. These are questions about the dignity and value of human life, about inter-human relations and about the God-human relationship.1 For this reason the paper starts with an exploration of the (...) implications of Christian anthropology, viewed from a Roman Catholic perspective. A set of conditions will be specified in the light of which germ-line gene therapy’s compatibility with Christian attitudes, a Christian understanding of the human being, and the meaning of human life can be assessed. (shrink)

The combination of genuine ethical concerns and fear of learning to use germ-line therapy for human disease must now be confronted. Until now, no established techniques were available to perform this treatment on a human. Through an integration of several fields of science and medicine, we have developed a nine step protocol at the germ-line level for the curative treatment of a genetic disease. Our purpose in this paper is to provide the first method to apply germ-line therapy to treat (...) those not yet born, who are destined to have a life threatening, or a severely debilitating genetic disease. We hope this proposal will initiate the process of a thorough analysis from both the scientific and ethical communities. As such, this proposal can be useful for official groups studying the advantages and disadvantages of germ-line therapy. (shrink)

Although the ability to perform gene therapy in human germ-line cells is still hypothetical, the rate of progress in molecular and cell biology suggests that it will only be a matter of time before reliable clinical techniques will be within reach. Three sets of arguments are commonly advanced against developing those techniques, respectively pointing to the clinical risks, social dangers and better alternatives. In this paper we analyze those arguments from the perspective of the client-centered ethos that traditionally governs practice (...) in medical genetics. This perspective clarifies the merits of these arguments for geneticists, and suggests useful new directions for the professional discussion of germ-line gene therapy. It suggests, for example, that the much discussed prospect of germ-line therapy in human pre-embryos may always be more problematic for medical genetics than adult germ-line interventions, even though the latter faces greater technical difficulties. (shrink)

We have surveyed various recent European opinions on Germ-Line engineering. The majority express more or less severe reservations about any interventions on the human Germ-Line, including therapeutic ones. However, they are divided over the pragmatic, or categorical-ethical nature of the relevant arguments. This split reflects two competing views of technology. The ‘pessimistic’ one is deeply concerned by the slippery slope leading from bona fide therapeutic applications of genetic engineering to eugenic practices. It insists that, if anything can defend us against (...) these evils, it must be a set of strong, ethically-based prohibitions. The other, ‘optimist’ view is more confident in the discriminating powers of societal regulation. We argue for the latter view and suggest that the pragmatic arguments brought to this debate are less problematic than the ethical ones. (shrink)

The application of genetic editing techniques for the prevention or cure of disease is a highly promising tool for the future of humanity. However, its implementation contains a number of ethical and legal challenges that should not be underestimated. On this basis, some sectors have already asked for a veto on any intervention that modifies the human germ line, while supporting somatic line editing. In this paper, I will support that this suggestion makes no sense at all, because the somatic/germ (...) line disjunctive has no moral relevance and, therefore, it should not play any role in legal terms. I will provide a number of reasons to hold this assumption, such as the non‐sacred nature of the germ line, the difference between germ line and human genome modification, or the moral importance of the presence of a will to create modified descendants. While doing so, I will provide some examples of the different approaches to germ line editing adopted by different regulations so as to demonstrate that, contrary to what is sometimes stated, a general ban on this practice is not the rule, but the exception. Additionally, I will show how alternative options which currently exist, such as a selective ban based on criteria different to the germ line/somatic line distinction, match better with the need to conciliate research needs and legitimate ethical concerns. Finally, I will introduce some further suggestions to this same purpose. (shrink)

The prospect of germ-line genetic engineering, the ability to engineer genetic changes that can be passed on to subsequent generations, raises a wide range of moral and public policy questions. One of the most provocative questions is, simply put: Are there moral reasons that can be articulated in general secular terms for accepting human nature as we find it? Or, at least in terms of general secular moral restraints, may we reshape human nature better to meet our own interests, as (...) we define them? This question in turn raises the further question of whether human nature as it now exists has a moral standing akin to sacredness that can be understood in nonreligious terms. This essay will take as a given that it is not possible to show in general secular moral terms that human nature has a sanctity or special moral standing that should guide secular health-care policy. In addition, as this essay shows, it is not possible through appeals to considerations of authorizing consent or beneficence toward others to remedy this failure to establish a sanctity or special moral standing for human nature. Absent a religious or culturally normative understanding of human nature and given the availability of germline genetic engineering, there is a plurality of possibilities for refashioning our nature. The unavailability of substantive secular moral constraints on germ-line genetic engineering discloses a secularly licit plurality of possibilities for human nature. The likelihood that we will be able to refashion our human nature reveals how few general secular moral constraints there are to guide us. Paradoxically, the more we are able to reengineer our human nature, the less guidance is available. The plurality of possible conceptions of human well-being that can be pursued through germ-line genetic engineering challenges our self-understanding as humans. Given human freedom, and in the absence of taken-for-granted religious or cultural moral constraints, the likelihood of germ-line genetic engineering opens the possibility of human nature in the plural. (shrink)

Enhancements of the human germ-line introduce further inequalities in the competition for scarce goods, such as income and desirable social positions. Social inequalities, in turn, amplify the range of genetic inequalities that access to germ-line enhancements may produce. From an egalitarian point of view, inequalities can be arranged to the benefit of the worst-off group (for instance, through general taxation), but the possibility of an indefinite growth of social and genetic inequality raises legitimate concerns. It is argued that inequalities produced (...) by markets of germ-line enhancements are just if it they are embedded in a framework of social institutions that satisfies two conditions: (i) Rawls’ Difference Principle, which states that inequalities of income and wealth should benefit the worst-off group; (ii) the lexically prior 'principle of rough equality', which states that citizens’ initial life-chances should be similar enough, so that extreme inequalities in income, wealth and power are not produced or accumulated through institutions justified by the Difference Principle. The principle of rough equality replaces the Rawlsian principles of the Fair Value of the Political Liberties and Fair Equality of Opportunity in a post-genomic society and expresses a concern with background political equality, which is argued to be a condition of the freedom and equality of citizens that should not be traded off with material benefits. Extreme inequalities are defined in terms of political equality. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Germ of a SenseMatthew TeichmanI find the account of metaphor offered in Donald Davidson's "What Metaphors Mean" fascinating for a number of reasons. The overall argument, that metaphors mean nothing other than what they mean literally, strikes me in many ways as absolutely right, and corrective of a certain tendency both in the humanities and in more popular forms of criticism to use the word "meaning" where it (...) doesn't apply. Of course, the other M word also has its history of abuse, whereby it often becomes a sort of last resort for closing down all discussion or counterargument: "You're missing the point—I was only being metaphorical." In these contexts "literal-mindedness" seems to take on a pejorative flavor, as though appealing to some clichéd stereotype of the math nerd whose every attempt to read a poem leaves him dumbfounded. While it is certainly true that metaphoric usages of words are more difficult to understand than their non-metaphoric counterparts, that there is something "extra" required in order to make sense of them, it is easy to fall into thinking that when we do succeed in making sense of them we are making use of a second species of meaning. Davidson's proposal is that we correct this sort of false picture by, as it were, uncrossing the wires; directing our attention to literal meaning is perfectly appropriate because it gives us a way of understanding more fully what metaphor is not.In what exactly this extra machinery might consist is of course the impossible question, on which Davidson remains understandably silent. One would suppose his model to fit more or less exactly with a picture of language that takes meaning to be the currency of compositional [End Page 567] semantics, and that nameless "something else" ("use," or "implied meaning," or whatever) to be the currency of pragmatics. Let metaphors "mean" only what it is that they mean regardless of their context, and leave the question of what it is that they "do" to your preferred theory of implicature or performative acts, or relevance. Fair enough. We will return later to how this larger perspective leads his theory to be cast in the particular way that it is. What he does end up saying about this mysterious something extra is along these lines: metaphors invite us to make a comparison between two things; they direct our attention to a similarity between them, in much the same way as similes. 1 This is obviously not the first time that similes have been invoked as a way of explaining metaphor; indeed, the formula "simile – 'like' = metaphor" has even made it into the grammar school curriculum. And how does this work, exactly? Let us imagine the most banal of examples: The Bard writes, "Those are pearls that were his eyes," 2 and we are invited to make a comparison between eyes and pearls, noticing all sorts of similarities; roundness, whiteness, immense value, etc.Further comparison between metaphors and similes yields the interesting observation that all similes are literally true, whereas their metaphoric counterparts are literally false. Our heavily schematized example, "His eyes are (like) pearls," seems to hold up to this claim. The idea appears to be that "similar" is really a trivial or vacuous predicate, because it is true of any pair of things that they are alike in some way. The way Davidson puts it, "This is like that—Tolstoy is like an infant, the earth is like a floor. It is trivial because everything is like everything, and in endless ways." 3 The problem is the following: when I say to you, "His eyes are like pearls," I am not really saying anything, because everything is like everything. All I am saying is that there exists some similarity between his eyes and pearls, when it is a given that there exists a veritable infinitude of rapports between any pair of things.Davidson's claim about similarity opens onto a fundamental problem, for which he doesn't try to propose any solution. On the one hand he appears to have hit upon an important insight, one that for instance explains why genre theory's... (shrink)

The germ theory of disease famously brought a new notion of specificity into concepts of disease. At the same time, the work of Pasteur, Koch and their colleagues was developed during the same decades as Charles Darwin's theories of evolutionary biology challenged traditional notions of the essentialism of biological species. This essay examines some of the ways in which Darwin's work was invoked by British doctors seeking to explain clinical or epidemiological anomalies, in which infectious diseases did not appear to (...) breed true. (shrink)

Due to the controversy surround his political war-time writings, Nishida Kitarō and his entire corpus has been accused of promoting and supporting Japanese imperialism. Despite the valid criticisms of his writings during the war-time period, Nishida’s early work in An Inquiry into the Good is not so easily interpreted as supporting nationalism. In fact, depending on the lens through which one reads Nishida’s early writings, one can even find the germs of emancipatory ideas that can easily be put in (...) dialogue with other liberatory thinkers such as Marx, Kropotkin, and Adorno. In this article, by considering the pluripotentiality of the text rather than a hermetically sealed off nationalist reading of it, I reread the ethical politics in An Inquiry into the Good through an emancipatory lens, considering how Nishida’s thought could have been taken up in a very different post-1911 Japan that did not move toward authoritarian militarism. Furthermore, I argue that the ambiguity surrounding his early political writings is consistent with his resistance to authoritarian ethics and his emphasis on the autonomy of the individual. (shrink)

This article is a response to David Jones’s “Germ-line Genetic Engineering: A Critical Look at Magisterial Catholic Teaching.” Here, Jones argues that the Magisterium’s teaching is inadequate in relation to germ-line genetic engineering (GGE) in that it neither settles the question of whether all GGE is illicit nor does it bring theological resources to bear on the issue. Jones himself argues against GGE, stating that it is not a therapy for a specific individual and that using the technique is incompatible (...) with the theology of marriage because children are not accepted as gifts. I argue that there is merit in Jones’s reasoning, as GGE can certainly be used in a manner contrary to the theology of marriage. However, I am less convinced as to whether Jones actually manages to make the case that GGE, in and of itself, may not be morally permissible. I would certainly agree with his ultimate conclusion that further theological reflection is needed. (shrink)

I.What are the genre characteristics of an autobiography? Is it journalism about anecdotes from the writer’s life? Or is it a personal fiction based on truthful memories that conveys the nature and logic of the writer’s youth? Biographies certainly differ from philosophical texts with their argumentative strategies. How was I to read Germs? If I just read on, like one reads a novel, I might overlook details relevant to the life recounted. Reading intently, in contrast—like you would a philosophy (...) book—might make one miss the peculiar scope of events. Anecdotes may lack insight into the social context, the psychological background, and the future of those involved. A remark from Aristotle about the difference between art (poetry) and history motivates me in this review. Poetry, Aristotle thinks, is more philosophical than history because it delivers universal knowledge:By universal truths are to be understood the kinds of thing a certain type of person will probably or necessarily say or do in a given situation; and this is the aim of poetry, although it gives individual names to its characters. The particular facts of the historian are what, say, Alcibiades did, or what happened to him. (Aristotle, 1986, 1451b7, p. 43–44). (shrink)

This chapter explores the general scientific changes in biology of evolutionary theory and germ theory as they were presented in the West during the nineteenth century. These are explored, in themselves, and then applied to general pattern that changed the practice of medicine then and set the stage for the way twentieth century medicine went forward.

This dissertation evaluates the ethical challenges posed by the prospect of human germ line gene transfer. It argues that GLGT presents a new, unprecedented and complex ethical challenge. While GLGT has not yet been attempted with human beings, it has the potential not only to introduce changes into human nature that are radical and different, but also to substantially affect attitudes about human dignity and human rights. This dissertation focuses on the principled ethical arguments and the frameworks, both rational and (...) theological, which must frame the practice of GLGT in order for it to be used in a constructive manner. Additionally it assesses which applications of GLGT are ethically acceptable, taking into account the different goals that GLGT will serve, the means by which it is practiced and the research that is required to make it possible. ;Chapter One reviews the history of genetics and genetic science, locating GLGT in the context of the rapid development in genetic science and biotechnology. Chapter Two examines the history of the debates about genetic engineering and GLGT, with particular focus on the political, regulatory, and theological analyses of the 1970s--1980s. Chapter Three explores the theoretical frameworks utilized by proponents and opponents of GLGT. Utilizing categories provided by Kurt Bayertz, principled arguments are delineated and analyzed based on whether they represent a substantialist or a subjectivist approach to human nature and identity. The shortcomings of each framework taken individually, and the impasse reached by the two sides of the debate evidence the need for an expanded ethical framework. The expanded ethical framework is comprised of an enhanced critical approach that draws on the critical thought of Gerald McKenny and Michel Foucault and of an enhanced appreciation for human embodiment that draws on Pope John Paul II's theology of the body. Chapter Four applies the principles identified in Chapter Three in the course of examining: the possible goals for applications of GLGT technology; the ethics of the means by which germ line changes could be introduced; and whether and how GLGT can be regulated. (shrink)

In this essay I discuss the contents and the context of Italian zoologist and entomologist Carlo Emery’s discussion of the germ-plasm theory. August Weismann considered him one of his very few creditable supporters, and encouraged him to publish his theoretical reflections. In his Gedanken zur Descendenz- und Vererbungstheorie, which appeared between 1893 and 1903 as a series of five essays in the journal Biologisches Zentralblatt, Emery developed a very personal account, applying the concept of determinants to problems like atavism, sexual (...) dimorphism, speciation, geographical isolation, transmission of characters, and putting forward, as early as 1903, the idea of a genetic program. (shrink)

I argue that neither realist nor anti-realist accounts of theory-change can account for the transition from zymotic views of disease to germ views. The trouble with realism is its focus on stable and continuous elements that get retained in the transition from one theory to the next; the trouble with anti-realism is its focus on the radical discontinuity between theories and their successors. I show that neither of these approaches works for the transition from zymes to germs: there is (...) neither continuity nor discontinuity, but, instead, a gradual evolution from zyme to germ views, during which germ elements are slowly incorporated into zymotic views until, eventually, none of the original zymotic constituents are left. I argue that the problem with both realism and anti-realism is that they rest on the unwarranted assumption that there are clearly delineated zymotic and germ theories as well as arguments for and against these theories, an assumption that does not hold. (shrink)

We develop the theory of germs of generic functions in simple theories. Starting with an algebraic quadrangle (or other similar hypotheses), we obtain an "almost" generic group chunk, where the product is denned up to a bounded number of possible values. This is the first step towards the proof of the group configuration theorem for simple theories, which is completed in [3].

Reproductive biotechnologies can separate concepts of parenthood into genetic, gestational and social dimensions, often leading to a fragmentation of heteronormative kinship models and posing a challenge to historical methods of establishing legal and/or moral parenthood. Using fictional cases, this article will demonstrate that the issues surrounding the intersection of current and emerging reproductive biotechnologies with definitions of parenthood are already leading to confusion regarding social and legal family ties for offspring, which is only expected to increase as new technologies develop. (...) Rather than opposing these new technologies to reassert traditional concepts of the family, however, this article will explore the opportunities that these technologies represent for re‐imagining various culturally cherished values of family‐making in a way that is inclusive of diverse genders, sexualities and cultures. It will consider IVF, gametogenesis, mitochondrial donation, surrogacy, artificial gestation, CRISPR‐Cas9 gene editing, foster care and adoption as some of many possible pathways to parenthood, including for members of the LGBTIAUQ+ community. (shrink)

Previous research has shown that the more individuals view observable entities as animate, the more those entities are associated with having psychological and physiological experiences. This study examined the relationship between children's animistic and anthropomorphic reasoning for concepts of unobservable scientific (i.e., germ) and religious (i.e., God) entities. This study further explored how children's conceptions vary according to the social learning opportunities (i.e., discourse, rituals) parents reportedly create. Parent–child dyads with young children from diverse ethnic and religious backgrounds participated. Three (...) central findings emerged. First, children readily associated God with psychobiological characteristics but did not do so to the same extent for germs. Second, children applied more psychobiological properties to both entity types when they believed that the entity was animate. Third, engaging in rituals and discourse with parents was indirectly related to children's concepts of God but not related to their concepts of germs. Overall, this study presented support for a connection between children's animistic and anthropomorphic reasoning for unobservable entities, and an indirect effect of cultural input on this reasoning. The implications of these findings will be discussed. (shrink)

Acute starvation can have long-term consequences that are mediated through epigenetic change. Some of these changes are affected by the activity of AMP-activated protein kinase, a master regulator of cellular energy homeostasis. In Caenorhabditis elegans, the absence of AMPK during a period of starvation in an early larval stage results in developmental defects following their recovery on food, while many of them become sterile. Moreover, the loss of AMPK during this quiescent period results in transgenerational phenotypes that can become progressively (...) worse with each successive generation. Our recent data describe a chromatin-based mechanism of how AMPK mediates adjustment to acute starvation in the germ cells, however, the heritable aspect of this AMPK mutant phenotype remains unresolved. Here, we explore how AMPK might affect this process and speculate how the initial transcription that occurs in the germ cells may adversely affect subsequent germline gene expression and/or genomic integrity. AMPK protects germ cell integrity during acute starvation by blocking inappropriate transcription. How these aberrant transcripts cause transgenerational defects is unclear. AMPK likely regulates germline integrity at multiple levels through several targets. The authors speculate here how AMPK disruption during starvation could result in the observed defects seen at each generation. (shrink)

Contributors to the debate surrounding the ethics of germ line gene manipulation have by and large concentrated their efforts on discussions of the potential risks that are associated with the use of this technology. Many international advisory committees have ruled out the acceptability of germ line gene manipulation at least for the time being. The purpose of this work is to generate much needed discussion on the many other ethical issues concerning the implementation of not only germ line gene manipulation (...) but also other related biotechnologies. In this paper I systematically investigate and analyse the most salient issues put forward by proponents and opponents alike. I argue that if germ line manipulation proves to be a safe and effective procedure, then the principle of beneficence imposes on the medical profession a moral duty to pursue the technology. (shrink)

Under the leadership of Joshua Lederberg, some American biologists and chemists proposed exobiology as the most legitimate program for space research. These scientists used the fear of contamination—of earth and other planets—as a central argument for funding “nonpolitical,” “scientifically valid” experiments in extraterrestrial life detection. Exobiology's resemblance to popular science fiction narratives presented a significant challenge to its advocates' scientific authority. Its most practical applications, moreover, bore an unseemly resemblance to the United States Army's research on biological weapons. At the (...) same time that exobiologists wanted to use the media to attract support for their program, they had to monitor their statements carefully in order to maintain their view of exobiology as a peaceful, scientifically valid research program. In examining how exobiology's creators positioned their work in comparison to other space sciences as well as science fiction, this case study highlights how cultural and political imperatives entered science through practice and narrative during the Cold War. Since there are still so many unanswered scientific questions and problems all around us on earth, why should we start asking new questions and seeking out new problems in space? How can the results justify the costs?—“Introduction to Outer Space” (1958). (shrink)

In the 1787 Transcendental Deduction of the Categories Kant indicates the only possible ways by which one can account for a necessary agreement of experience with the concepts of its objects (B166), using analogies between modes of explanation and biological theories about the origin of life. He endorses epigenesis as a model for his system of pure reason (B167). This paper examines various interpretive claims about the meaning of this theory of generation and its significance for Kant’s philosophy (Section 1), (...) showing that, after his Critical shift in perspective, in 1775/77 Kant already combined preformed elements and their purposively oriented formation by natural forces (Section 2). Contrary to the standard view, Kant’s theory of race appears to constitute the background to assess Blumenbach’s later (1799/1781) shift to epigenesis after supporting Haller’s preformism (Section 3). In Section 4, I argue that the ground of affinity between epigenesis and formal idealism rests in tracing the first origin of these conformities: externala posterioriclimate conditions and predisposed germs and dispositions within the generative power of the human body; and externala posterioriexperience and spontaneousa prioriconcepts of its objects, within pure sensory intuiting and pure thinking. In both cases the external empirical conditions would function as occasioning propelling factors affecting internal pre-established forms of generation. (shrink)

Germ-line genetic interventions, like all medicine, can present opportunities to remove suffering, save and prolong human life, and support the conditions for successful human performance. Like all medicine, these interventions also present risks that reflect fallen humans’ age-old egocentric ambition to secure their health and improve their quality of life by relying exclusively on their own power, wisdom, and technical means. Moreover, man has always been tempted to overstep Divine prohibitions and to disregard his own calling to become deified by (...) grace. Wherever man succumbs to such tendencies, this inescapably leads to a disruption of the vital relationship between man and God. The legitimacy of the intervention itself depends on the theological status of the genome. Orthodox theology recognizes that the human genome, just as everything else that is created, must be understood in terms of its relationship to God. This consideration, however, does not mean that it can be idolized or is therefore untouchable. Interventions and alterations can be accepted within the constraints set by God, as formulated in the theology of creative logoi of beings in the teaching of the Fathers of the Church, and thus in view of man’s divine vocation. The Christian acceptability or inacceptability of human germ-line gene therapy depends directly on the extent to which it accords with an Orthodox spiritual life, or else hinders such a life. In this sense, this intervention can be examined in the same way as the application of all medical knowledge. When this is used to relieve pain and is motivated by selfless love for one’s neighbor, then it can be considered God’s gift to humankind. When, however, it becomes an absolute and attempts to usurp the presence of God in human life, then use becomes abuse and modern man faces yet another form of idolatry, even though more refined than earlier forms. (shrink)

Germ cell segregation and gamete production are developmental problems that all sexually reproducing species must solve in order to survive. Many people are familiar with the complex social structures of some insect species, where specialised castes of adult insects perform specific tasks, one of which is usually to guard the sexually reproductive queen. The parasitic wasp Copidosoma floridanum adds another level of complexity to the caste system: a fertilised egg produces both sterile, short‐lived “soldier” larvae and “reproductive” larvae that complete (...) metamorphosis to produce sexually reproductive adults. How two morphologically and functionally distinct larval castes are produced by genetically identical groups of cells developing under the same environmental conditions is a baffling problem. A recent paper suggests that differential germ cell segregation during embryogenesis may be an event both necessary and sufficient for caste determination.1 BioEssays 26:1263–1267, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This article is written from within the Catholic, and more particularly the Augustinian/Thomist tradition of moral theology. It analyses the response of the Catholic Magisterium to the prospect of germline-genetic engineering (GGE). This is a very new issue and the Church has little definitive teaching on it. The statements of Popes and Vatican congregations or commissions have not settled the key questions. An analysis of theological themes drawn from secular writers points beyond pragmatic safety considerations toward intrinsic ethical limits to (...) GGE. Given the impossibility of identifying would-have-been-created persons who would be “treated” by this intervention, altering the human genome for the sake of future generations cannot be regarded as “therapy.” Further theological considerations suggest that GGE may not be morally permissible, even in the case of identifiable genetic diseases. This is an area where more theological reflection is needed. (shrink)

Many strands of research by different groups, starting from teratocarcinomas in the laboratory mouse, later moving the corresponding human tumors, contributed to the isolation and description of human pluripotent stem cells (PSCs). In this review, I highlight the contributions from my own research, particularly at the Wistar Institute during the 1980s, when with my colleagues we characterized one of the first clonal lines of pluripotent human embryonal carcinoma (EC) cells, the stem cells of teratocarcinomas, and identified key features including cell (...) surface antigen markers that have since found a place in the study and exploitation of human PSC. Much of this research depended upon close teamwork with colleagues, many in other laboratories, who contributed different expertise and experience. It was also often driven by circumstance and chance rather than pursuit of a grand design. (shrink)

In 1982, the President's Commission produced its report on human gene therapy. One of that report's recommendations was to expand the Recombinant DNA Advisory Committee to the National Institutes of Health to include a subcommittee on human gene therapy. In 1984, the Human Gene Therapy Subcommittee was established, and in 1989 it produced a document—“Points to Consider for Protocols for the Transfer of Recombinant DNA into Human Subjects”—that stated the RAC's position on what sorts of protocols it would approve.In assessing (...) the impact of the President's Commission report, Alexander Capron wrote,[t]he line [the report] drew between somatic cell and germ-line therapies has shaped subsequent discussions and policy formulation. Its conclusion … that somatic cell therapy resembles medical treatment is the basic premise of the RAC subcommittee's “Points to Consider,” while the Commission's view that ethical as well as technical barriers preclude present attempts to alter germ cells continues to be generally accepted by scientists and nonscientists alike. (shrink)

Determinations of the ethical acceptability of genetic therapy have relied on several distinctions in attempts to separate ethically acceptable genetic therapy from those possible therapies that could lead to genetic modifications of future human beings. One distinction that has been proposed is that genetic modifications of human somatic cells is ethically acceptable but that Germ-Line genetics modifications would be ethically objectionable. This paper examines several serious difficulties which call into question the ethical relevance of a somatic/Germ-Line distinction. Keywords: double effect, (...) future generations, Germ-Line modification CiteULike Connotea Del.icio.us What's this? (shrink)