Holobionts are symbiotic assemblages composed by a macrobe host plus its symbiotic microbiota. In recent years, the ontological status of holobionts has created a great amount of controversy among philosophers and biologists: are holobionts biological individuals or are they rather ecological communities of independent individuals that interact together? Chiu and Eberl have recently developed an eco-immunity account of the holobiont wherein holobionts are neither biological individuals nor ecological communities, but hybrids between a host and its microbiota. According to their (...) account, the microbiota is not a proper part of the holobiont. Yet, it should be regarded as a set of scaffolds that support the individuality of the host. In this paper, we approach Chiu and Eberl’s account from a metaphysical perspective and argue that, contrary to what the authors claim, the eco-immunity account entails that the microorganisms that compose the host’s microbiota are proper parts of the holobiont. Second, we argue that by claiming that holobionts are hybrids, and therefore, not biological individuals, the authors seem to be assuming a controversial position about the ontology of hybrids, which are conventionally characterized as a type of biological individual. In doing so, our paper aligns with the contemporary tendency to incorporate metaphysical resources to shed light on current biological debates and builds on that to provide additional support to the consideration of holobionts as biological individuals from an eco-immunity perspective. (shrink)

The emerging field of synthetic biology aims to engineer novel biological entities. The envisioned future bio-based economy builds largely on “cell factories”: organisms that have been metabolically engineered to sustainably produce substances for human ends. In this paper, we argue that synthetic biology’s goal of creating efficient production vessels for industrial applications implies a set of ontological assumptions according to which living organisms are machines. Traditionally, a machine is understood as a technological, isolated and controllable production unit consisting of parts. (...) But modified organisms, or hybrids, require us to think beyond the machine paradigm and its associated dichotomies between artificial and natural, organisms and artefacts. We ask: How may we conceptualise hybrids beyond limiting ontological categories? Our main claim is that the hybrids created by synthetic biology should be considered not as machines but as metabolic systems. We shall show how the philosophical account of metabolism can inform an ontology of hybrids that moves beyond what we call the “machine ontology”, considering that metabolism enables thinking beyond the dominant dichotomies and allows us to understand and design lifeforms in a bio-based economy. Thus, the aim of this paper is twofold: first, to develop the philosophical ontology of hybrids, and second, to move synthetic biology beyond the problematically limiting view of hybrids. (shrink)

Recent developments in biotechnology allow for the generation of increasingly complex products out of human tissues, for example, human stem cell lines, synthetic embryo-like structures and organoids. These developments are coupled with growing commercial interests. Although commercialisation can spark the scientific and clinical promises, profit-making out of human tissues is ethically contentious and known to raise public concern. The traditional bioethical frames of gift versus market are inapt to capture the resulting practical and ethical complexities. Therefore, we propose an alternative (...) approach to identify, evaluate and deal with the ethical challenges that are raised by the increasing commercialisation of the exchange of sophisticated human tissue products. We use organoid technology, a cutting-edge stem cell technology that enables the cultivation of ‘mini-organs’ in a dish, as an example. First, we examine the moral value of organoids and recognise them as hybrids that relate to persons and their bodies as well as to technologies and markets in ambiguous ways. Second, we show that commercialisation of organoids is legitimised by a detachment of the instrumental and commercial value of organoids from their associations with persons and their bodies. This detachment is enacted in steps of disentanglement, among which consent and commodification. Third, we contend that far-reaching disentanglement is ethically challenging: (1) Societal interests could be put under pressure, because the rationale for commercialising organoid technology, that is, to stimulate biomedical innovation for the good of society, may not be fulfilled; (2) The interests of donors are made subordinate to those of third parties and the relational moral value of organoids may be insufficiently recognised. Fourth, we propose a ‘consent for governance’ model that contributes to responsible innovation and clinical translation in this exciting field. (shrink)

In contrast to earlier views that argued for a particular kind of concept, several recent accounts have proposed that there are multiple distinct kinds of concepts, or that there is a plurality of concepts for each category. In this paper, I argue for a novel account of concepts as pluralistic hybrids. According to this view, concepts are pluralistic because there are several concepts for the same category whose use is heavily determined by context. In addition, concepts are hybrids (...) because they typically link together several different kinds of information that are used in the same cognitive processes. This alternative view accounts for the available empirical data, allows for greater cognitive flexibility than Machery's recent account, and overcomes several objections to traditional hybrid views. (shrink)

The prospect of creating and using human–animal chimeras and hybrids that are significantly human-like in their composition, phenotype, cognition, or behavior meets with divergent moral judgments: on the one side, it is claimed that such beings might be candidates for human-analogous rights to protection and care; on the other side, it is supposed that their existence might disturb fundamental natural and social orders. This paper tries to show that both positions are paradoxically intertwined: they rely on two kinds of (...) species arguments, “individual species arguments” and “group species arguments,” which formulate opposing demands but are conceptually interdependent. As a consequence, the existence of HACHs may challenge exactly those normative standards on which the protection of HACHs may eventually be based. This ethical paradox could constitute the ultimate source of the “moral confusion” that some authors have suspected HACHs to provoke. (shrink)

When people combine concepts these are often characterised as “hybrid”, “impossible”, or “humorous”. However, when simply considering them in terms of extensional logic, the novel concepts understood as a conjunctive concept will often lack meaning having an empty extension (consider “a tooth that is a chair”, “a pet flower”, etc.). Still, people use different strategies to produce new non-empty concepts: additive or integrative combination of features, alignment of features, instantiation, etc. All these strategies involve the ability to deal with conflicting (...) attributes and the creation of new (combinations of) properties. We here consider in particular the case where a Head concept has superior ‘asymmetric’ control over steering the resulting concept combination (or hybridisation) with a Modifier concept. Specifically, we propose a dialogical approach to concept combination and discuss an implementation based on axiom weakening, which models the cognitive and logical mechanics of this asymmetric form of hybridisation. (shrink)

Kafka's Creatures: Animals, Hybrids, and Other Fantastic Beings is an interdisciplinary collection of essays on Franz Kafka's use of non-human creatures in his writings. It is written from a variety of interpretive perspectives and highlights diverse ways of understanding how Kafka's use of these creatures illuminate his work in general.

This chapter covers the duality theory for closure algebras and Heyting algebras. The notion of a hybrid of topology and order is introduced, and the fundamental properties of hybrids are studied. It is proved that the category of hybrids and hybrid maps is dually equivalent to the category of closure algebras and closure algebra homomorphisms, while the category of strict hybrids and hybrid maps is dually equivalent to the category of Heyting algebras and Heyting homomorphisms. The notion (...) of a Grzegorczyk algebra is introduced, and several characterizations of these algebras are given using the duality theory. From these characterizations it follows that the category of skeletal closure algebras is a subcategory of the category of Grzegorczyk algebras. Finally, it is proved that the variety of Grzegorczyk algebras is generated by its finite members, and some consequences of this result are derived. (shrink)

What if the Big Bang was an exodus of non-existing reality into existence? In this book a theory of the reality is started from the principle that 'existing takes time' but in states of the universe there are pre-things in moments, thus non-existing, which realize in strings over specific time intervals as existing phenomena. Causality must be reviewed now and new paradigms for reality follow. The existing and observed universe are discontinuous and "limits" in mathematical models do not correspond to (...) reality. New interpretations in evolution theory and the human condition are being investigated. (shrink)

What if the Big Bang was an exodus of non-existing reality into existence? In this book a theory of the reality is started from the principle that 'existing takes time' but in states of the universe there are pre-things in moments, thus non-existing, which realize in strings over specific time intervals as existing phenomena. Causality must be reviewed now and new paradigms for reality follow. The existing and observed universe are discontinuous and "limits" in mathematical models do not correspond to (...) reality. New interpretations in evolution theory and the human condition are being investigated. (shrink)

This paper uses the advent of human-animal hybrids, created though somatic cell nuclear transfer experiments in America and Australia, as a tool to deconstruct and challenge the dualistic belief that humans are morally distinct and superior to animals. The view that moral value corresponds to species membership creates a scientific and cultural environment that prohibits or restricts human embryo experimentation whilst permitting the extensive use of animals for research. The dualistic premise therefore motivates the creation of human-animal hybrids (...) for research as a way for scientists to side-step restrictive legislation. Furthermore, ethical frameworks that incorporate the dualistic assumption have been incapable of objectively assessing the moral value of hybrid embryos. This failure indicates the arbitrariness of the moral dichotomy between animals and humans. Moral dualism, based on species membership, should be replaced with a liberal ethical framework based on a consistent standard such as interests. (shrink)

Until recently, medicine has had little to offer most of the millions of patients suffering from rare and ultrarare genetic conditions. But the development in 2019 of Milasen, the first genetic intervention developed for and administered to a single patient suffering from an ultrarare genetic disorder, has offered hope to patients and families. In addition, Milasen raised a series of conceptual and ethical questions about how individualised genetic interventions should be developed, assessed for safety and efficacy and financially supported. The (...) answers to these questions depend in large part on whether individualised therapies are understood as human subjects research or clinical innovation, different domains of biomedicine that are regulated by different modes of oversight, funding and professional norms. In this article, with development and administration of the drug Milasen as our case study, we argue that at least some individualised genetic therapies are not, as some have argued, either research or treatment. Instead, they are research-treatment hybrids, a category that has both epistemological and pragmatic repercussions for funding, ethics oversight and regulation. (shrink)

Machery's case against hybrids rests on a principle that is too strong, even by his own lights. And there are likely important generalizations to be made about hybrids, if they do exist. Moreover, even if there were no important generalizations about concepts themselves, the term picks out an important class of entities and should be retained to help guide inquiry.

not only anomalous animals, but also exemplary animals often take on a symbolic value, thus raising a second problem. A solution to both problems is suggested, based on an examination of the cognitive..

In the pages of this journal, a fruitful debate has evolved on the ethical legitimacy of fractional-reserve banking. In this article, we respond to the new arguments raised by Evans as we clarify our position on the unethical and illegitimate nature of fractional-reserve banking. Fractional-reserve banking is not a recent financial innovation but represents a long-standing legal aberration. The co-mingling of two mutually exclusive financial contracts, deposit and loan, confounds the contracting parties’ purposes, intents, rights, and obligations. As a result, (...) it creates unsolvable legal difficulties and ethical dilemmas. While these problems are most evident in the case of a bank run, they also arise when trying to answer the simple question of “who owns a deposit?”. (shrink)

Epistemic category violations and hybrids arouse cognitive attention, and form sticky cultural memes that help social in-group bonding. This article discusses the cognitive science around monster hybrids and adds the important missing ingredient of affective/emotional systems.

This second exploration of how the relationships between technology and animality are understood and represented by Levi focuses mostly on his science fiction and on how it challenges the human-animal divide as it was instead presented in “A Bottle of Sunshine.” The analysis of the overarching theme of hybridity in Levi’s work shows in fact that Levi represents himself as indeed a homo faber, who nonetheless needs a hybrid literary strategy capable of displaying the creative possibilities of limitrophy as well (...) as the hubris of traditional anthropocentric humanism. (shrink)

Developments in biological technology in the last few decades highlight the surprising and ever-expanding practical benefits of stem cells. With this progress, the possibility of combining human and nonhuman organisms is a reality, with ethical boundaries that are not readily obvious. These inter-species hybrids are of a larger class of biological entities called “chimeras.” As the concept of a human-nonhuman creature is conjured in our minds, either incredulous wonder or grotesque horror is likely to follow. This paper seeks to (...) mitigate those worries and demotivate reasonable concerns raised against chimera research, all the while pressing current ethical positions toward their plausible conclusions. -/- In service of this overall aim, first, I intend to show that chimeras are far less foreign and fantastic in light of recent research in the lab; second, I intend to show that anti-realist (so-called “constructivist”) commitments regarding species ontology render the species distinction (i.e., the divide between human and nonhuman) superfluous as a basis for ethical practice; and third, I discuss some prevailing dignity accounts regarding the practical ethics of the creation, research, and treatment of chimeras. Consequently I intend to show that the adoption of this particular set of views (constructivist ontology, capacity-based ethics) in conjunction with recent research ought to justify a parallel with what we accord to humans persons, and that trajectory allows for cases of moral permissibility. (shrink)

This paper presents a preliminary and tentative formulation of a novel empirical generalization governing the relationship between grammar and cognition across a variety of independent domains. Its point of departure is an abstract distinction between two kinds of cognitive structures: symmetric and asymmetric. While in principle any feature whatsoever has the potential for introducing asymmetry, this paper focuses on one specific feature, namely thematic-role assignment. Our main empirical finding concerns the role of language, or, more specifically, grammar, in effecting and (...) maintaining the distinction between symmetric and asymmetric cognitive structures. Specifically, whereas symmetric structures devoid of thematic-role assignment more commonly occur in a non-grammatical and usually also non-verbal medium, asymmetric structures involving thematic-role assignment are more likely to be associated with a grammatical medium. Our work draws together three independent strands of empirical research associated with three diverse phenomenological domains: compositional semantics, metaphors and schematological hybrids. These three domains instantiate conceptual combinations, bringing together two or more subordinate entities into a single superordinate entity. For compositional semantics this consists of a juxtaposition of constituent signs to form a single more complex sign; for metaphors this entails the bringing together of two different concepts in order to produce a comparison; while for schematological hybrids this involves the combination of different entities to form a single new hybrid entity. Our empirical results reveal a remarkable parallelism between the above three domains. Within each domain, symmetric structures tend to be associated with a non-verbal or otherwise non-grammatical medium, while asymmetric structures are more frequently associated with a grammatical medium. Thus, within each domain, grammar introduces asymmetry. More specifically, we find that in all three domains, the asymmetry in question is one that involves the assignment of thematic roles. To capture this effect, we posit two distinct levels, or tiers, of cognition: non-grammatical cognition, more commonly associated with symmetric structures, and grammatical cognition more conducive to asymmetric structures. Within each of the three phenomenological domains, we find the distinction between non-grammatical and grammatical cognition to be manifest in three independent realms, phylogeny, ontogeny, and the architecture of human cognition. (shrink)

Hybridisations between related species with divergent ontogenies can provide insights into the bases for evolutionary change in development. One example of such hybridisations involves sea urchin species that exhibit either standard larval (pluteal) stages or those that develop directly from embryo to adult without an intervening feeding larval stage. In such crosses, pluteal features were found to be restored in fertilisations of the eggs of some direct developing sea urchins (Heliocidaris erythrogramma) with the sperm of closely (Heliocidaris tuberculata) and distantly (...) (Pseudoboletia maculata) related species with feeding larvae. Such results can be argued to support the punctuated equilibrium model—conservation in pluteal regulatory systems and a comparatively rapid switch to direct development in evolution.1,2 Generation of hybrids between distantly related direct developers may, however, indicate evolutionary convergence. The ‘rescue’ of pluteal features by paternal genomes may require maternal factors from H. erythrogramma because the larva of this species has pluteal features. In contrast, pluteal features were not restored in hybridisations with the eggs of Holopneustes purpurescens, which lacks pluteal features. How much of pluteal development can be lost before it cannot be rescued in such crosses? The answer awaits hybridisations among indirect and direct developing sea urchins differing in developmental phenotype, in parallel with investigations of the genetic programs involved. BioEssays 26:343–347, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

RNA polymerase II is recruited to DNA double‐strand breaks (DSBs), transcribes the sequences that flank the break and produces a novel RNA type that has been termed damage‐induced long non‐coding RNA (dilncRNA). DilncRNAs can be processed into short, miRNA‐like molecules or degraded by different ribonucleases. They can also form double‐stranded RNAs or DNA:RNA hybrids. The DNA:RNA hybrids formed at DSBs contribute to the recruitment of repair factors during the early steps of homologous recombination (HR) and, in this way, (...) contribute to the accuracy of the DNA repair. However, if not resolved, the DNA:RNA hybrids are highly mutagenic and prevent the recruitment of later HR factors. Here recent discoveries about the synthesis, processing, and degradation of dilncRNAs are revised. The focus is on RNA clearance, a necessary step for the successful repair of DSBs and the aim is to reconcile contradictory findings on the effects of dilncRNAs and DNA:RNA hybrids in HR. (shrink)

The article is devoted to the analysis of the?Pussy riot? case and the peculiarities of Russian postsecularism. Special emphasis is placed on the phenomenon of post-secular hybrids, i.e. the overcoming of the situation of social differentiation between religion and other social subsystems. It is claimed that the materials of the trial against?Pussy riot? make evident the appearance in Russia of at least three post-secular hybrids: 1) the blending of religion and politics; 2) installation of religious norms into the (...) public order of the secular state; 3) significance of confessional legal experts as part of the new?ideological state apparatus?. Slucaj?Pusi rajot? postao je glavni religijski, ako ne i drustveno-politicki dogadjaj u Rusiji u 2012. godini. Autor ce na osnovu analize materijala koji se odnosi na navedeni slucaj i diskusije koje su potom usledile, pokusati da pokaze specificnosti ruskog iskustva desekularizacije i prelaza prema novoj situaciji postsekularizma. Kroz prizmu sudjenja ucesnicima pank molebana bice razmotreni postsekularni hibridi nastali kao rezultat desekularizacije, u kojima su cudnovato isprepleteni religijski i svetovni elementi. Radi se o tri postsekularna hibrida: ukrstanju religijske i sekularne sfere, ukrstanju religije i javnog poretka i pojavi konfesionalnih religiologa - eksperata. (shrink)

The article aims to present issues arising out of differences in the way that the terms chimera and hybrid are defined in legal systems and by natural sciences in the context of mixing human and animal DNA. The author analyses the different approaches to defining these terms used in various legal systems, dividing them into groups in light of conclusions reached from examining definitions used in natural sciences. The distinction is used to answer the question of which approach to definitions (...) applied by legislators is the best way to handle the subject of human-animal organisms, given the need to balance their impact on medicine and the ethical concerns that arise. (shrink)

ABSTRACT When does a state of affairs constitute a harm to someone? Comparative accounts say that being worse off constitutes harm. The temporal version of the comparative account is seldom taken seriously, due to apparently fatal counterexamples. I defend the temporal version against these counterexamples, and show that it is in fact more plausible than the prominent counterfactual version of the account. Non-comparative accounts say that being badly off constitutes harm. However, neither the temporal comparative account nor the non-comparative account (...) can correctly classify all harms. I argue that we should combine them into a hybrid account of harm. The hybrid account is extensionally adequate and presents a unified view on the nature of harm. (shrink)

This chapter surveys hybrid theories of well-being. It also discusses some criticisms, and suggests some new directions that philosophical discussion of hybrid theories might take.

Hybrid languages have both modal and first-order characteristics: a Kripke semantics, and explicit variable binding apparatus. This paper motivates the development of hybrid languages, sketches their history, and examines the expressive power of three hybrid binders. We show that all three binders give rise to languages strictly weaker than the corresponding first-order language, that full first-order expressivity can be gained by adding the universal modality, and that all three binders can force the existence of infinite models and have undecidable satisfiability (...) problems. (shrink)

Hybrid logics are a principled generalization of both modal logics and description logics, a standard formalism for knowledge representation. In this paper we give the first constructive version of hybrid logic, thereby showing that it is possible to hybridize constructive modal logics. Alternative systems are discussed, but we fix on a reasonable and well-motivated version of intuitionistic hybrid logic and prove essential proof-theoretical results for a natural deduction formulation of it. Our natural deduction system is also extended with additional inference (...) rules corresponding to conditions on the accessibility relations expressed by so-called geometric theories. Thus, we give natural deduction systems in a uniform way for a wide class of constructive hybrid logics. This shows that constructive hybrid logics are a viable enterprise and opens up the way for future applications. (shrink)

In recent years an increasing quantity of UK legislation has introduced blended or ‘hybridised’ procedures that blur the previously clear demarcation between civil and criminal legal processes, typically on the grounds of normatively-motivated political expediency. This paper provides a critical perspective on instances of procedural hybridisation in order to illustrate that, first, the reliance upon civil law measures to remedy criminal law infractions can raise human rights issues and, second, that such instrumental criminal justice strategies deliberately circumvent the enhanced procedural (...) protections of the criminal law. By conceptualising the rule of law as a structural coupling between the political and legal systems, and due process rights as necessary and self-imposed limitations upon systemic operations, this paper employs a systems-theoretical approach to critique this balancing act between expediency and principle, and queries the circumstances under which legislation contravening the rule of law can be said to lack legitimacy. (shrink)