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Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD) and...
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Genomics yields biological and phenotypic insights into bipolar disorder
Bipolar disorder is a leading contributor to the global burden of disease
1 . Despite high heritability (60–80%), the majority of the underlying...
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Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient...
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CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
BackgroundThe Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic...
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The Healthy Trinity to Face Non‐communicable Diseases: Physical Activity, Nutrition and Sleep
Non-communicable diseases (NCDs), such as diabetes, cancerCancers, and heart disease, are significant global healthHealth concerns. Under the...
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Optimizing Nutrition for Exercise and Sports
Athletes should follow these rules in order to optimize their nutrition. Eat enough calories to offset energy expenditure (typically...
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%
1 , much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study...
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Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the...
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International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance
Based on a comprehensive review and critical analysis of the literature regarding the effects of sodium bicarbonate supplementation on exercise...
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Mapping the human genetic architecture of COVID-19
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social...
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Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics
Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are...
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Effects of a low-carbohydrate ketogenic diet on health parameters in resistance-trained women
PurposeThe aim of this study was to evaluate the effect of a ketogenic diet on blood pressure, visceral adipose tissue (VAT), bone mineral content...
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases...
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Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
Supplementing with creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery....
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central...
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Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?
An amendment to this paper has been published and can be accessed via the original article.
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Mapping and characterization of structural variation in 17,795 human genomes
A key goal of whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, including single-nucleotide variants,...
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Is diet partly responsible for differences in COVID-19 death rates between and within countries?
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and...
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The athletic gut microbiota
The microorganisms in the gastrointestinal tract play a significant role in nutrient uptake, vitamin synthesis, energy harvest, inflammatory...